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Targeting miR-375 in gastric cancer.
Xu Y, Deng Y, Yan X, Zhou T. Xu Y, et al. Expert Opin Ther Targets. 2011 Aug;15(8):961-72. doi: 10.1517/14728222.2011.581232. Epub 2011 May 11. Expert Opin Ther Targets. 2011. PMID: 21557705 Review.
The genes targeted by miR-375, including JAK2 and 3'-phosphoinositide dependent protein kinase-1 (PDK1), are also candidates for gastric cancer therapy. EXPERT OPINION: Although radical surgery and rational chemotherapy are still the main treatment for gastric cancer, targ …
The genes targeted by miR-375, including JAK2 and 3'-phosphoinositide dependent protein kinase-1 (PDK1), are also candidates for gast …
Overexpression of 3-phosphoinositide-dependent protein kinase-1 is associated with prognosis of gastric carcinoma.
Bai X, Li P, Xie Y, Guo C, Sun Y, Xu Q, Zhao D. Bai X, et al. Tumour Biol. 2016 Feb;37(2):2333-9. doi: 10.1007/s13277-015-4024-8. Epub 2015 Sep 15. Tumour Biol. 2016. PMID: 26373731

The expression of PDK1 was analyzed by real-time quantitative PCR and immunohistochemistry method. ...The 5-year survival rate was 20.1 and 63.4 % of the patients with high and low expression level of PDK1, respectively (P < 0.05). The median survival length was

…
The expression of PDK1 was analyzed by real-time quantitative PCR and immunohistochemistry method. ...The 5-year survival rate was 20 …
LncRNA AC093818.1 accelerates gastric cancer metastasis by epigenetically promoting PDK1 expression.
Ba MC, Ba Z, Long H, Cui SZ, Gong YF, Yan ZF, Lin KP, Wu YB, Tu YN. Ba MC, et al. Cell Death Dis. 2020 Jan 27;11(1):64. doi: 10.1038/s41419-020-2245-2. Cell Death Dis. 2020. PMID: 31988283 Free PMC article.
AC093818.1 overexpression promoted GC migration and invasion in vitro and in vivo. AC093818.1 overexpression increased PDK1, p-AKT1, and p-mTOR expression levels. AC093818.1 silencing decreased these expressions. ...The data demonstrate that lncRNA AC093818.1 accelerates g …
AC093818.1 overexpression promoted GC migration and invasion in vitro and in vivo. AC093818.1 overexpression increased PDK1, p-AKT1, …
[Effects of Astragalin on apoptosis of undifferentiated gastric cancer cells].
Chu ZH, He SY, Wang Y, Zhu RT, Gu YL, Chen JY. Chu ZH, et al. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022 Sep;38(5):520-524. doi: 10.12047/j.cjap.6259.2022.097. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2022. PMID: 37088763 Chinese.
At the same time, Astragalin up-regulated the transcription levels of genes bax and bad, down-regulated the transcription levels of genes egf, egfr, pik3cb, pdk1, akt3 and bcl-2. Western blot analysis also showed that the expressions of PI3K and Akt protein were decreased, …
At the same time, Astragalin up-regulated the transcription levels of genes bax and bad, down-regulated the transcription levels of genes eg …
UFM1 suppresses invasive activities of gastric cancer cells by attenuating the expres7sion of PDK1 through PI3K/AKT signaling.
Lin JX, Xie XS, Weng XF, Qiu SL, Yoon C, Lian NZ, Xie JW, Wang JB, Lu J, Chen QY, Cao LL, Lin M, Tu RH, Yang YH, Huang CM, Zheng CH, Li P. Lin JX, et al. J Exp Clin Cancer Res. 2019 Sep 18;38(1):410. doi: 10.1186/s13046-019-1416-4. J Exp Clin Cancer Res. 2019. PMID: 31533855 Free PMC article.
Further studies have revealed that UFM1 could increase the ubiquitination level of PDK1 and decrease the expression of PDK1 at protein level, thereby inhibiting the phosphorylation level of AKT at Ser473. Additionally, the effect of UFM1 on gastric cancer cell funct …
Further studies have revealed that UFM1 could increase the ubiquitination level of PDK1 and decrease the expression of PDK1 at …
MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta.
Tsukamoto Y, Nakada C, Noguchi T, Tanigawa M, Nguyen LT, Uchida T, Hijiya N, Matsuura K, Fujioka T, Seto M, Moriyama M. Tsukamoto Y, et al. Cancer Res. 2010 Mar 15;70(6):2339-49. doi: 10.1158/0008-5472.CAN-09-2777. Epub 2010 Mar 9. Cancer Res. 2010. PMID: 20215506
Interestingly, we found that expression of miR-375 inhibited expression of PDK1, which is a direct target of miR-375, followed by suppression of Akt phosphorylation. ...The activity of a luciferase reporter containing the miR-375 binding sequence at the 3' untranslated reg …
Interestingly, we found that expression of miR-375 inhibited expression of PDK1, which is a direct target of miR-375, followed by sup …
PAK1 silencing is synthetic lethal with CDK4/6 inhibition in gastric cancer cells via regulating PDK1 expression.
Qian Y, Wu X, Wang H, Hou G, Han X, Song W. Qian Y, et al. Hum Cell. 2020 Apr;33(2):377-385. doi: 10.1007/s13577-019-00317-6. Epub 2020 Jan 9. Hum Cell. 2020. PMID: 31919718
Consistently, PAK1 ablation increased GC cell sensitivity exposed to CDK4/6 inhibitor and promoted DNA damage. We also revealed PAK1 depletion notably affected PDK1-AKT pathway, and PDK1 overexpression totally abrogated the effect of PAK1 deletion on DNA damage in G …
Consistently, PAK1 ablation increased GC cell sensitivity exposed to CDK4/6 inhibitor and promoted DNA damage. We also revealed PAK1 depleti …
G-protein coupled receptor 34 knockdown impairs the proliferation and migration of HGC-27 gastric cancer cells in vitro.
Jin ZT, Li K, Li M, Ren ZG, Wang FS, Zhu JY, Leng XS, Yu WD. Jin ZT, et al. Chin Med J (Engl). 2015 Feb 20;128(4):545-9. doi: 10.4103/0366-6999.151114. Chin Med J (Engl). 2015. PMID: 25673461 Free PMC article.
The proliferation, migration of these cells were examined by Cell Counting Kit-8 and transwell. We also measured expression profile of PI3K/PDK1/AKT and ERK using Western blotting. RESULTS: The ShRNA directed against GPR34 effectively inhibited both endogenous mRNA and pro …
The proliferation, migration of these cells were examined by Cell Counting Kit-8 and transwell. We also measured expression profile of PI3K/ …
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